Melanotan II is a synthetic cyclic analogue of alpha-melanocyte-stimulating hormone, developed at the University of Arizona as a melanocortin receptor research tool. It is supplied strictly for laboratory research into melanocortin signalling.
Melanotan II is a cyclic heptapeptide analogue of α-MSH, the hormone that signals melanocytes to produce pigment. It activates multiple melanocortin receptors (MC1R, MC3R, MC4R, MC5R), which is why it has been used in research spanning pigmentation, appetite and other signalling pathways.
Its research history is genuinely notable: an off-target MC4R effect observed during early studies directly led to the development of bremelanotide (PT-141), which became an FDA-approved medicine. Melanotan II itself was never taken through a completed regulatory development programme.
It is an unlicensed compound with well-documented safety concerns in the case literature, and the MHRA has issued standing public warnings about melanotan products marketed for human use. PMR PHARMA supplies it solely as a laboratory reference material for receptor research.
Findings from the published literature, with the evidence level stated honestly for every claim.
Binds MC1R, MC3R, MC4R and MC5R — a broad melanocortin receptor probe used across pigmentation and signalling research.
MechanismAn off-target effect observed in Melanotan II studies led directly to bremelanotide — now an FDA-approved drug.
HistoryA stabilised cyclic analogue of the body's own melanocyte-stimulating hormone.
Chemistry| Compound | Melanotan II (MT-2) |
|---|---|
| CAS number | 121062-08-6 |
| Molecular weight | ~1,024.2 Da |
| Content | 10 mg — lyophilised vial |
| Purity | ≥99% (HPLC) — batch COA supplied |
| Form | Lyophilised powder |
| Storage | 2–8 °C, protected from light |
Store lyophilised at 2–8 °C or −20 °C, protected from light. Reconstituted solution should be refrigerated at 2–8 °C.
As a broad melanocortin receptor agonist, it is used to study pigmentation biology and MC receptor signalling pathways in laboratory models.
No. It is not an approved medicine in any country, and the UK MHRA has issued standing public warnings about melanotan products marketed for human use. It is supplied strictly for laboratory research.
Independent third-party HPLC purity and mass-spectrometry identity testing per batch, with COAs available on request.
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